AM replied: "1) both can create constipation and then consequently hemorroids. 2) can conflict with drugs: Other medicines-Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking a narcotic analgesic, it is especially important that your health care professional know if you are taking any of the following: * Carbamazepine (e.g., Tegretol)-Propoxyphene may increase the blood levels of carbamazepine, which increases the chance of serious side effects * Central nervous system (CNS) depressants or * Monoamine oxidase (MAO) inhibitor activity (isocarboxazid [e.g., Marplan], phenelzine [e.g., Nardil], procarbazine [e.g., Matulane], tranylcypromine [e.g., Parnate] (taken currently or within the past 2 weeks) or * Tricyclic antidepressants (amitriptyline [e.g., Elavil], amoxapine [e.g., Asendin], clomipramine [e.g., Anafranil], desipramine [e.g., Pertofrane], doxepin [e.g., Sinequan], imipramine [e.g., Tofranil], nortriptyline [e.g., Aventyl], protriptyline [e.g., Vivactil], trimipramine [e.g., Surmontil])-The chance of side effects may be increased; the combination of meperidine (e.g., Demerol) and MAO inhibitors is especially dangerous * Naltrexone (e.g., Trexan)-Narcotics will not be effective in people taking naltrexone * Rifampin (e.g., Rifadin)-Rifampin decreases the effects of methadone and may cause withdrawal symptoms in people who are dependent on methadone * Zidovudine (e.g., AZT, Retrovir)-Morphine may increase the blood levels of zidovudine and increase the chance of serious side effects 3) Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Get emergency help immediately if any of the following symptoms of overdose occur : Cold, clammy skin; confusion; convulsions (seizures); dizziness (severe); drowsiness (severe); low blood pressure; nervousness or restlessness (severe); pinpoint pupils of eyes; slow heartbeat; slow or troubled breathing; weakness (severe) Also, check with your doctor as soon as possible if any of the following side effects occur: Less common or rare Dark urine (for propoxyphene only); fast, slow, or pounding heartbeat; feelings of unreality; hallucinations (seeing, hearing, or feeling things that are not there); hives, itching, or skin rash; increased sweating (more common with hydrocodone, meperidine, and methadone); irregular breathing; mental depression or other mood or mental changes; pale stools (for propoxyphene only); redness or flushing of face (more common with hydrocodone, meperidine, and methadone); ringing or buzzing in the ears; shortness of breath, wheezing, or troubled breathing; swelling of face; trembling or uncontrolled muscle movements; unusual excitement or restlessness (especially in children); yellow eyes or skin (for propoxyphene only) Other side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. However, check with your doctor if any of the following side effects continue or are bothersome: More common Dizziness, light-headedness, or feeling faint; drowsiness; nausea or vomiting Less common or rare Blurred or double vision or other changes in vision; constipation (more common with long-term use and with codeine); decrease in amount of urine; difficult or painful urination; dry mouth; false sense of well-being; frequent urge to urinate; general feeling of discomfort or illness; headache; loss of appetite; nervousness or restlessness; nightmares or unusual dreams; redness, swelling, pain, or burning at place of injection; stomach cramps or pain; trouble in sleeping; unusual tiredness or weakness After you stop using this medicine, your body may need time to adjust. The length of time this takes depends on the amount of medicine you were using and how long you used it. During this period of time check with your doctor if you notice any of the following side effects: Body aches; diarrhea; fast heartbeat; fever, runny nose, or sneezing; gooseflesh; increased sweating; increased yawning; loss of appetite; nausea or vomiting; nervousness, restlessness, or irritability; shivering or trembling; stomach cramps; trouble in sleeping; unusually large pupils of eyes; weakness Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor. Check for any conflicts with meds or conditions you may or situations such as breastfeeding, seizure disorders, etc., which I'm sure your doctor covered."